In contrary, different selective small-molecule CGRP antagonists achieved clinical status for the treatment of migraine, including BIBN4096BS/olcegepant (186) (NCT02194777, NCT02194322, etc.), MK-0974/telcagepant (187) (NCT01294709, NCT00432237, etc.), MK-3207 (188) (NCT00712725, NCT00548353), and the very recently Food and Drug Administration (FDA)-approved MK-1602/ubrogepant (Ubrelvy®) (189) (NCT04179474, NCT02867709, etc.). The gene discussed is CALCA; the disease is migraine disorder.