On the other hand –and as part of the same study–, although authors suggest that the in vitro cell proliferation, invasion, and migration activated by exogenous AM would be mediated by both AM1 and AM2, RAMP2 was barely detected in the renal cancer cell lines employed (786-O and BIZ) (134), indicating that they may not be representative models of that cancer. The gene discussed is ADM2; the disease is cancer.