On the other hand, the list of anti-CGRP agents with therapeutic action in migraine is not limited only to antagonists of the CLR/RAMP1 receptor, but also contains the commercially available, CGRP-neutralizing antibody fremanezumab (Ajovy®) (190) (NCT03308968, NCT04041284, etc.). The gene discussed is CALCA; the disease is migraine disorder.