We performed IHC detection on CD3+T cells, CD68+ macrophages, CD20+ B cells and CD57+ NK cells in the tumor tissues of 1,328 patients.CD3+T cells and CD68+ macrophages infiltration increased significantly in EBVaGC patients (CD3+, mean ± SD, 23.84 ± 14.49 vs. 12.76 ± 8.93, P < 0.001, Figure 2A; CD68+, 9.73 ± 5.25 vs.5.44 ± 4.18, P < 0.001, Figure 2B). This evidence concerns the gene CD68 and neoplasm.