Among the pathways, those that were involved in HNSCC tumorigenesis and pathogenesis were cytokine-cytokine receptor interaction, the IL-17 signaling pathway, the NF-kappa B signaling pathway, malaria, pathways in cancer, fluid shear stress and atherosclerosis, and toxoplasmosis. The gene discussed is IL17A; the disease is head and neck squamous cell carcinoma.