AVP and atherosclerosis: ADH patients are characterized by elevated LDL-C levels, which result in excess deposition of cholesterol in tissues, leading to accelerated atherosclerosis and increased risk for premature CHD [4]. All the monogenic forms of ADH exhibit a gene dosage effect with the severest phenotypes observed in homozygous and compound or double heterozygous carriers, who may, if left untreated, already develop overt CHD in their second decade of life [6,7].