In a previous study, we verified that exosomal miR‐141‐3p derived from MDA PCa 2b cells promotes osteoblast activity and osteoblastic bone metastasis (Ye et al., 2017), and another study demonstrated that cancer‐derived hsa‐miR‐940 induces osteogenesis by targeting ARHGAP1 and FAM134A (Hashimoto et al., 2018). The gene discussed is RETREG2; the disease is cancer.