Amongst this signature, we selected 6 genes presenting the most important differences in microarrays plus2 (and confirmed in other transcriptome analyses) and which were representative of the BC subgroups: IRF1, LC3B and ATG5 whose expression was increased in TNBC; BECN1 and ATG2B whose expression was increased in the ER group (HER+ or -) and finally, ULK1 whose expression was elevated in ER and HER2 groups compared to TNBC. This evidence concerns the gene IRF1 and breast cancer.