TXNIP and breast cancer: Similarly, using ROC plotter, a high expression of TXNIP was associated with a significant higher response to any chemotherapy (p = 3.2E-2) and seemed to be also associated with a higher response to endocrine therapy (p = 0.08) confirming that TXNIP expression was associated with a good prognosis, independently of the grade of the BC (Supplemental Figure 6C).