IL6 and colorectal carcinoma: The results of a study in a mouse model of CRC induced by azoxymethane showed that the structure of the intestinal microbiota was regulated by Clostridium butyricum administered by gavage, which involved a reduction of the ratio of Firmicutes/Bacteroidetes, an increase in the relative abundance of probiotics, an increase in tumor cell apoptosis, inhibition of the NF-κB pathway and IL-6 levels, and a reduction in CRC incidence [103].