ENO2 and lung carcinoma: Currently, traditional tumor-associated antigen (TAA) biomarkers, such as cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), carbohydrate antigen (CA) 125, CA15-3, CA19-9, and CA72-4, remain widely used as reference diagnoses for lung cancer [9, 10] (Isaksson, Jonsson et al. 2017, Seijo, Peled et al. 2019).