The top 20 pathways most significantly associated with disease were as follows: Chagas disease (American trypanosomiasis), allograft rejection, toxoplasmosis, hepatitis B, inflammatory bowel disease (IBD), intestinal immune network for IgA production, malaria, rheumatoid arthritis, autoimmune thyroid disease, HIF-1 signaling pathway, T-cell receptor signaling pathway, cytokine-cytokine receptor interaction, leishmaniasis, Toll-like receptor signaling pathway, amoebiasis, pathways in cancer, asthma, measles, graft-versus-host disease, and FoxO signaling pathway. The gene discussed is CD79A; the disease is American trypanosomiasis.