TNF and chronic obstructive pulmonary disease: In addition, it is reported that P. ternata can be used to reverse various adverse effects of the withdrawal of ICS, such as a rebound in goblet cell number, mucin 5AC (MUC5AC) expression, and interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) levels, used for the treatment of COPD [4].