NSD1 and Sotos syndrome: Mutations known to be causal for Sotos syndrome that localized to the plant homeodomain (PHD) regions of the encoded protein diminished NSD1 binding to specific methylated sites (H3K4 and H3K9), and abrogated cofactor recruitment (e.g., Nizp1), which collectively lead to impairments in normal transcriptional regulation (Pasillas et al., 2011).