Taking an example for SP1, SP1 was considered as a cancer gene only by MinNetRank and was ranked 3rd, 3rd, 3rd, 2nd, 3rd,and 1st in TCGA-LIHC, LIRI-LIHC, TCGA-STAD, TCGA-BLCA, TCGA-LUAD, and TCGA-SKCM, respectively (Supplementary Table 1). This evidence concerns the gene SP1 and cancer.