FGL2 is a membrane-bound or secreted protein expressed by macrophages, T cells, and tumor cells that has coagulation activity and immunosuppressive functions (Marazzi et al., 1998); it was found to promote mammary tumor progression by enhancing tumor angiogenesis or inducing epithelial-to-mesenchymal transition (Rabizadeh et al., 2015). This evidence concerns the gene FGL2 and neoplasm.