“METTL4-NDC80,” “C1orf109-CDCA,” and “TMEM60-PHTF2” with the score of 1 consistently played protective roles across multiple types of cancer, while pairs like “ATAD2-WDYHV1” and “AURKA-CSTF1” with the score of 1 seemed to be associated with cancer progression and a worse survival across multiple cancer types. Here, PHTF2 is linked to cancer.