PLAGL2 and colorectal cancer: Here is a very recent report that PLAGL2-POFUT1 were proved to synergistically promote colorectal tumorigenesis by maintaining stemness of colorectal cancer stem cells, and modifying or editing transcriptional binding sites in their bidirectional promoter simultaneously suppressed both PLAGL2 and POFUT1 expression, which could offer promising therapeutic approaches (Li et al., 2019).