Our single cell RNA-Seq data analysis results showed that CD95, TNF-α and IL-1β are co-expressed in CD95+ monocytes and macrophages in aortas and peripheral blood (Supplementary Figures 7 and 8), and CD95 expressions are increased in MHO aortas in hyperlipidemia conditions (Figure 6). The gene discussed is TNF; the disease is hyperlipidemia.