FAS and systemic lupus erythematosus: Further analysis of the downregulated innate immune genes in CD95 KO with the Ingenuity Pathway Analysis (IPA) showed that the top eight pathways of inflammation, including Th1 pathway, NF-ĸB signaling, systemic lupus erythematosus in B cells, cardiac hypertrophy signaling, production of nitric oxide and reactive oxygen species, neuroinflammation, systemic lupus erythematosus in T cells, and hepatic fibrosis signaling, were significantly downregulated (z score ≤1) compared with WT controls (Supplementary Figure 5B).