B cells from B6.Nba2.BΔIFNAR mice did not show production of Ifit2 in response to IFN-αA stimulation, whereas B cells from WT B6.Nba2 lupus-prone control mice upregulated Ifit2 levels by ~25 fold (Figure 1B). This evidence concerns the gene IFIT2 and systemic lupus erythematosus.