• What are LAG3 expression levels on innate T cells, B cells and pDCs during autoimmunity, cancer or infectious disease?• What regulates LAG3 endocytosis?• How does LAG3 RNA level correspond to surface expression? o Intracellular stores, endocytosis, and cleavage from cell surface complicate inferences of surface expression from RNA expression.• Does endocytosed LAG3 maintain function?• What % of intracellular LAG3 is de novo vs endocytosed? This evidence concerns the gene LAG3 and infectious disease.