In line with its role in MM, we found that IL-27 levels progressively decrease in the advanced stages of disease, even without reaching a statistical significance (SMM vs. MMD vs. MMR pg/ml: 1303 vs. 870.1 vs. 478.7, Kruskal-Wallis test, p = 0.07) (Figure 4C). Here, IL27 is linked to Miyoshi myopathy.