As for PD-L1, we performed analysis focusing on patients with active MM and we showed that patients with ISS = II and III have higher CD8+PD-1+% (II + III vs. I, 4.42 vs. 2.48, Mann-Whitney test, p = 0.007), but not CD4+PD-1+% (II + III vs. I, 3.91 vs. 3.79, Mann-Whitney test, p = 0.462), as compared with ISS = I patients (Supplementary Figures 3A, B). This evidence concerns the gene PDCD1 and Miyoshi myopathy.