CD274 and Miyoshi myopathy: Conversely, PD-L1 up-regulation on PCs and monocytes was detected after in vitro treatment of BM MNCs with IFN-γ; these data thus suggest that in vitro data do not reflect in vivo effects of this cytokine in BM niche, possibly due to a dilution of IFN-γ in the sera and suggesting the use of alternative methods to quantify this cytokine in the focal lesion of MM patients.