Indeed, our analysis identified a number of genes common to all three datasets that have been previously demonstrated to play important roles in pSS pathogenesis including several members of the CXC chemokine family of cytokines including CXCL9, CXCL10, CXCL11, CXCL13 (15, 51, 52), members of the guanylate-binding protein family; GBP1, GBP5 (49, 53, 54), as well as AIM2 (55), CD52 (56), and GZMK (57). This evidence concerns the gene CD52 and peeling skin syndrome.