C5AR1 and neoplasm: The reduced generation of Tregs when C5aR1 signaling was blocked, with a specific C5aR1 inhibitor (PMX53) (110), was caused by the decreased production of TGF-β1 and increased expression of IL-6 in myeloid cells in tumor infiltrating lymph nodes (109), as the interplay between these two cytokines is pivotal for generating various subsets of T cell effectors (111).