In addition to regulating myeloid-origin cells such as MDSC and tumor-associated macrophages (TAM) (112), C5aR1 and the complement anaphylatoxin C3a receptor (C3aR) synergistically impair cytolytic activity of tumor infiltrating CD8+T cells (TIL) by inhibiting expression of IL-10 in these cells (113). The gene discussed is C5AR1; the disease is neoplasm.