We found that iNOS+ KCs (a proinflammatory M1 phenotype) were significantly increased in HD and MD group mice compared to control group mice at 2 weeks, while CD206+ KCs (an anti-inflammatory M2 phenotype) were not significantly changed between these groups at 2, 12, and 24 weeks, but the percentage and absolute numbers of CD206+ KCs were higher than iNOS+ KCs and represented approximately 70% of KCs during the time course (Figures 4A, B; Supplemental Figures S2, S3). This evidence concerns the gene MRC1 and Menkes disease.