The TIL protocol consists of three basic steps: (i) patient preconditioning by lymphodepleting regimen; (ii) Isolation of TIL from tumor biopsies and ex-vivo expansion of generated TIL cultures with the anti-CD3 antibody OKT3, irradiated feeder cells and IL-2; (iii) TIL administration i.v. followed by IL-2 infusion. This evidence concerns the gene IL2 and neoplasm.