In mice with MC38 and Sa1N tumors, LAG3 monotherapy was generally ineffective with very limited tumor clearance and slight reduction of tumor growth, whereas dual blockade of LAG3 and PD1 synergistically restricted tumor growth and achieved tumor clearance in 80% of mice compared with 40% remission in mice receiving anti-PD1 monotherapy (55). The gene discussed is PDCD1; the disease is neoplasm.