To determine whether F. nucleatum could regulate the proliferation of DLD-1 and SW480 cells and whether Cdk5 could play a role in the F. nucleatum-mediated effect, CRC cell lines (DLD-1 and SW480) and Cdk5-knockdown cells were inoculated with F. nucleatum 25,586 (MOI 100). Here, CDK5 is linked to colorectal carcinoma.