NLRP3 and rheumatoid arthritis: Vande Walle et al. indicated that the rheumatoid arthritis susceptibility gene A20 was lacking, increasing the expression of pro-IL-1β and NLRP3 genes, which led to caspase-1 activation mediated by the NLRP3 inflammasome, IL-1β secretion, and the occurrence of pyroptosis, although a deficiency of NLRP3 greatly suppressed this process (100).