THAP1 and Dystonia: A very recent systematic review and meta-analysis of GPi-DBS for monogenic dystonia found robust support for DYT1, modest support for DYT6 and PANK2-related dystonia, and promising results for SGCE, DYT3, ACTB and GNAO1-related dystonia, supporting the concept of a differential outcomes for the individual monogenic forms (143).