For example, the aggregates generated by the overexpression of the tau repeat domain with an FTD-17 mutation (TauRDΔK280) (252) as well as the proteolytically cleaved tau isoform D421 (Tau-C3) (260) are degraded by macroautophagy in cell models of tauopathy. The gene discussed is MAPT; the disease is tauopathy.