Using the same murine model of tauopathy, it has been demonstrated that brains of 12-month-old Tg mice displayed significantly reduced activities of complex I and V. In these animals, tau-induced mitochondrial dysregulation worsened with aging, since 24-month-old mice showed increasingly reduced electron transport capacity and ATP levels, together with incremented ROS levels (H2O2 and superoxide anion radicals) (217). Here, MAPT is linked to tauopathy.