The results also suggest that studies in recent decades, have increasingly focused on the relationships between the gut microbiota and potential depression-related disorders (e.g., Alzheimer's disease, inflammatory bowel disease, irritable bowel syndrome, Parkinson's disease, and bipolar disorder), as well as the underlying mechanisms, involving the immune system, intestinal permeability, bacterial translocation, cytokines such as necrosis factor-alpha, CRP, and the microbiota-gut-brain axis. The gene discussed is CRP; the disease is early-onset autosomal dominant Alzheimer disease.