Besides the increase in fibrinogen level, one of the most remarkable laboratory features of the hypercoagulable state in COVID-19 patients is the unusually high von Willebrand factor levels, up to 10 times the upper normal limit and higher than the normal range in 100% of the patients (Panigada et al., 2020; Voicu et al., 2020b); factor VIII level is subsequently very elevated, as factor VIII is transported by von Willebrand factor (Tabatabai et al., 2020; Panigada et al., 2020; Voicu et al., 2020b). This evidence concerns the gene VWF and thrombophilia.