PTGS2 and hypertensive disorder: It is known that angiotensin II contributes to the development of hypertension by its vasoconstrictor action and modulating prostaglandin production as a consequence of the regulation of COX-2 expression (Ohnaka et al., 2000; Harris et al., 2004; Alvarez et al., 2007; Beltrán et al., 2009; Hernanz et al., 2014).