SLC1A2 and Alzheimer disease: In line with these observations, neuronal hyperexcitability observed in 5 × FAD mice was attenuated by increasing the expression of GLT-1 and by reducing changes in dendrite morphology, synaptic strength, and NMDA/AMPA receptors activity ratios after inhibiting the nuclear factor of activated T cells 4 (Sompol et al., 2017), a protein overactivated in the early stages of AD (Abdul et al., 2009).