Interestingly, it was found recently that restoring slow gamma oscillation (40 Hz) in a non-invasive manner by simply exposing AD mice to 1 h of 40 Hz tons per day for a week was sufficient to reduce amyloid and tau pathologies not only in the auditory cortex but also in the hippocampus, to activate microglia, and to improve cognitive performance (Martorell et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.