This reuptake suppression was shown to be induced by lower levels and membrane diffusion obstruction of the astroglial excitatory amino-acid transporter 2 (EAAT2; termed GLT-1 in mice) (Jacob et al., 2007; Hefendehl et al., 2016; Zott et al., 2019), a glutamate transporter that is predominant in the CA1 area and whose activity is reduced in the early stages of AD (Masliah et al., 1996; Hefendehl et al., 2016). Here, SLC1A2 is linked to Alzheimer disease.