The disruption of the activity and expression of GS and the two main Glu transporters in the Central Nervous System (CNS), the Na+- dependent Glu and aspartate transporter (GLAST/EAAT1) and Glu transporter1 (GLT-1/EAAT2) have been described in advanced liver injuries such as HE and hyperammonemia (Waniewski, 1992; Butterworth, 2002; Bémeur and Butterworth, 2013; Hu et al., 2018; Sohn et al., 2018). The gene discussed is SLC1A3; the disease is hereditary elliptocytosis.