To determine the role of mitochondrial outer membrane protein, voltage-dependent anion channel 1 protein (VDAC1) in AD, the Reddy group (Manczak and Reddy, 2012b) used brain specimens from AD patients and control subjects and 6-, 12- and 24-month-old Aβ precursor protein transgenic mice to assess VDAC1 protein levels. The gene discussed is VDAC1; the disease is Alzheimer disease.