To determine the role of mitochondrial outer membrane protein, VDAC1 and its interaction with p-tau in AD, the Reddy group (Manczak and Reddy, 2012b) studied the interaction between VDAC1 and phosphorylated tau, using cortical tissues from AD patients, control subjects, APP, APP/PS1, and 3XTg.AD mice. Here, PSEN1 is linked to Alzheimer disease.