Interestingly, although we found that the PhenoAge clock had the lowest correlation with chronologic age in brain tissue, initial analyses by Levine et al. (2018) suggested that PhenoAge in the ROSMAP DLPFC was also significantly related to amyloid load, to neurofibrillary tangles, as well as to pathologic AD diagnosis. The gene discussed is CLOCK; the disease is Alzheimer disease.