For MMP-2, MMP-8, TIMP-2, IL-1β, and TNF-α, no significant differences were found between the sepsis groups, and no correlations were found to the 8 parameters of overall sepsis scoring classifying horses as septic (≥10/19 points) or nonseptic (≤9/19 points) or the 3 subgroups (negative, questionable, positive). This evidence concerns the gene MMP8 and Sepsis.