Further work will be required to determine whether the impaired killing capacity of CARD9-deficient neutrophils is a major contributor to fungal infection in these patients, how CARD9-deficient neutrophils operate their organ-specific functions against fungal infection in the CNS and skin, and why CARD9-deficient neutrophils exhibit a selective defect in fungal killing predisposing the host to C. albicans and P. verrucosa infection but not Aspergillus infection. This evidence concerns the gene CARD9 and fungal infectious disease.