Considering the important role of the adenosinergic pathway in the suppression of the antitumor immune response through Ado generation [13] and that the presence of high concentrations of extracellular nucleotides in the TME of CC seems to interfere with the regulation, proliferation, differentiation, and apoptosis of cancer cells of the cervix [49], the concentrations and activity of CD39 and CD73 in the plasma of patients with CC may be valuable biomarkers of disease progression and may direct the choice of clinical treatment for these patients. The gene discussed is ENTPD1; the disease is cancer.