DUX4 and Ewing sarcoma: In addition, over the last decade, two new histological variants of Ewing sarcoma have been described that result from either a t(4; 19) (q35; q13) or a t(10; 19) (q35; q13) translocation or chromosome X paracentric inversion to generate CIC-DUX4 or BCOR-CCNB3 fusion proteins, respectively [23, 24].