The forthcoming WHO Classification of Tumours of Soft Tissue and Bone will leverage molecular diagnostics and subclassify Ewing and Ewing-like sarcomas into four categories inclusive of genetic translocation: Ewing sarcoma, EWSR1 round cell sarcoma with non-ETS partners, CIC sarcomas, and BCOR sarcomas (Figure 1). This evidence concerns the gene EWSR1 and sarcoma.