Autophagy is critically coordinated by the action of a set of several key components, including ATG, and is regulated by intricate networks, such as mTOR.45 NM derivatives have been found to stimulate autophagy via inhibition of the mTOR signaling pathway in cancer cells.8,46 In our study, we found that NM-mediated autophagy activation occurred independently of mTOR regulation in keratinocytes. The gene discussed is MTOR; the disease is cancer.