HMGB1 and early-onset autosomal dominant Alzheimer disease: HMGB1 is a non-histone nuclear protein that can function as a pathogenic inflammatory response in a number of conditions in the brain, including epilepsy [60], septic shock [61], ischemia [62], traumatic brain injury [63], Parkinson’s disease [64], Alzheimer’s disease [65] and multiple sclerosis [66].