IL-2, IL-6 and TNF-α were all induced to significantly lesser extents in the cortexes of the infected TLR4mut mice compared with the infected TLR4WT mice at day 4 PI, but they were induced to similar levels in the brains of both genotypes by VEEV TC-83 infection at days 2, 6 and 8 PI. The gene discussed is IL6; the disease is infection.