TAF1 and X-linked dystonia-parkinsonism: Further evidence for a crucial role of the cerebello-thalamic projection in the pathophysiology of dystonia comes from X-linked dystonia-parkinsonism (XDP), an inherited adult-onset neurodegenerative disorder with striking striatal and pallidal volume loss (Hanssen et al. 2018, 2019) and widespread pathology of the white matter (Bruggemann et al. 2016; Blood et al. 2018) due to a mutation in the TAF1 gene (Aneichyk et al. 2018; Westenberger et al. 2019).