In keeping, RNA-mediated knockdown of the α3-containing sodium pumps led to a phenotype of dystonia-parkinsonism (Fremont et al. 2015) which corresponds to the human disease of rapid-onset dystonia-parkinsonism caused by mutations in the gene encoding the α3-subunit of the sodium–potassium pump (Brashear et al. 2007). Here, ATP12A is linked to Parkinson disease.