CYP26A1 and type 1 diabetes mellitus: While RA signaling is decreased in the livers of fasted mice, it appears to be increased in the livers of mice with T1D as indicated by the upregulated expression of Cyp26A1. Western blot analysis shows a substantial increase in the RDH10 protein content in microsomal membranes from Ins2Akita mice, which correlates with the increase in total RDH activity.