An alanine-to-threonine change at position 391 of ZIP8 resulting from a nonsynonymous SNP (rs13107325C→T) in SLC39A8 is associated with a variety of diseases including Crohn's disease (242, 243), severe idiopathic scoliosis (244), and circulating lipid levels and risk of coronary artery disease (245). Here, SLC39A8 is linked to idiopathic scoliosis.