While it may be difficult to ascertain the chicken and egg sequence within this positive feedback loop between hyperinsulinemia inducing increased brain activation of SNS tone [37–40] and increased SNS tone inducing hyperinsulinemia and insulin resistance [9–13, 15, 32], the current findings suggest that it may be possible that each pathology shares certain common etiological factors, that include altered SCN clock control of cardiometabolic health as a function of persistent low dopamine input activity to this center. The gene discussed is CLOCK; the disease is Insulin resistance.