Given the association of diminished circadian peak dopaminergic activity at the peri-SCN area with insulin resistance and the presence of dopamine D1 and D2 receptors in the SCN and peri-SCN regions [24], we hypothesized that a chronic diminution of dopaminergic input activity to the peri-SCN/SCN clock area is actually operative in facilitating the obese, hyperinsulinemic/insulin resistant and hypertensive state. Here, CLOCK is linked to Insulin resistance.