Increased prevalence of APOE ε4 allele among amnestic forms of AD has also raised the hypotheses that APOE ε4 is an anatomically selective risk factor that increases vulnerability to AD pathology (ADP) in memory-related medial temporal regions and that it possibly modulates the clinical phenotype of AD through the influence of specific large scale brain networks [10, 11]. Here, APOE is linked to Alzheimer disease.