In this study, we discovered that HOTAIRM1 was highly expressed in PCOS tissues and cells, and upregulation of HOTAIRM1 suppressed the proliferation and promoted the apoptosis of ovarian granulose cells (KGN), which suggested that HOTAIRM1 may perform a crucial role in the progression of PCOS. Here, HOTAIRM1 is linked to polycystic ovary syndrome.