Moreover, based on sensitivity to EGFR- and pan-ERBB-specific TKIs, our previous studies identified subsets of EGFR/ERBB-dependent HNSCC cell lines and used functional genomics strategies to define EGFR, ERBB2 and ERBB3 as components of a non-mutated driver pathway [7–9]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.