CXCL9 and neoplasm: In this regard, preclinical studies have shown the capacity of antibodies targeting chemokine receptors, intra-tumoral injection of recombinant proteins (CXCL9/10), or epigenetic modifiers that dis-inhibit chemokine expression to attract immune cells capable of reducing tumor burden and prolonging survival in various murine cancer models [46, 59, 60].