Herein, we measured transcriptional reprogramming in a panel of human HNSCC cell lines that exhibit equivalent growth sensitivity to EGFR/ERBB inhibitors and observed marked heterogeneity in both the magnitude and complexity of a TKI-induced interferon response program including diverse chemokines and cytokines that signal to immune cells in the tumor microenvironment [34–36]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.