We recently defined EGFR-dependent human HNSCC cell lines based on sensitivity to EGFR-specific TKIs where the mean IC50 values for gefitinib and AZD8931 across the panel are 20.4 ± 3.1 and 4.1 ± 1.9, respectively [7–9, 43]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.