To define pathways responsible for innate immune gene and chemokine induction, the human HNSCC cell lines UMSCC8 and UMSCC25 were treated with gefitinib in combination with either a JAK/STAT inhibitor, ruxolitinib, or an IKK/NFκB inhibitor, IKK16. Here, SOAT1 is linked to head and neck squamous cell carcinoma.