ERBB2 and head and neck squamous cell carcinoma: Moreover, based on sensitivity to EGFR- and pan-ERBB-specific TKIs, our previous studies identified subsets of EGFR/ERBB-dependent HNSCC cell lines and used functional genomics strategies to define EGFR, ERBB2 and ERBB3 as components of a non-mutated driver pathway [7–9].