Analysis of those nine WHIM syndrome like mutations shows that almost all result in premature truncated proteins, leading to a loss of serine and threonine residues at the C-terminus of CXCR4, including G323fs343X, L329fs341X, R334X, G336X, S338X, S339fs342X, S341fs365X and E343X, only one mutation association with a single case of WHIM syndrome family from North Carolina causes one residue change from E (glutamic acid) to K (lysine) (CXCR4E343K) at the 343 site of the CXCR4 tail, but no loss of serine and threonine residues for phosphorylation (Fig. 1a, b) [2, 14, 15]. This evidence concerns the gene CXCR4 and WHIM syndrome.