Moreover, the analysis with the anti-OTC antibody reveals a chimeric liver consisting of large colonies of OTC+ human hepatocytes, presumably originating from OTC-corrected human hepatocytes interspersed with equally large colonies of cells that still react with antibodies to human hepatocyte cytokeratins, but that are not detected with antibodies for human OTC, which presumably originate from the unedited, original OTCD hepatocytes. The gene discussed is OTC; the disease is ornithine carbamoyltransferase deficiency.